Comparison of Efficacy of Topical with Oral Ciprofloxacin in Patients of Tubotympanic Type of Chronic Suppurative Otitis Media to Obtain Dry Ear

Background: Chronic suppurative otitis media (CSOM) is one of the common diseases in routine ENT practice. Objective: To compare the efficacy of topical ciprofloxacin with oral ciprofloxacin 500mg twice daily in achieving dry ear (Medical cure) in Tubo-tympanic type of Chronic suppurative otitis media. Methodology: Study Design: Quasi-experimental study. Place and st Duration of Study: The study was carried out at ENT department of Bahawal Victoria Hospital Bahawalpur from 01 January to th 30 September 2015. One hundered patients, 11 to 60 years of age of either gender having Tubo-tympanic type of chronic supportive otitis media were included. Patients with previous antibiotic treatment, pregnant or lactating women, history of hypersensitivity to Quinolones (ciprofloxacin), chronic suppurative otitis media of Attico-antral type, known case of DM and hypertension were excluded. Selected patients were divided into two groups (Group A& Group B) by using lottery method. Group A (n=50) was given Ciprofloxacin ear drops and Group B (n=50) was given Oral Ciprofloxacin 500mg twice daily. The patients were followed up to 08 weeks after treatment (at least two follow up visits) and examined otoscopically and under microscope to assess the efficacy. The efficacy of drugs was graded into four grades depending upon the decrease in discharge amount (Poor/no response, satisfactory, good and excellent). The data was entered and analyzed by using SPSS version 20. Results: The mean age of group A patients was 27 ± 5 and in group B was 30 ± 5 years. Males were 67 (67%) and females were 33 (33%) with ratio of 2:1. Bilateral CSOM in 27 (27%) and Unilateral was found in 73 patients (73%). Efficacy was excellent in 52%, good in 24%, satisfactory in 8% and poor/ no response in 11% patients of Group A while it was excellent in 36%, good in 24%, satisfactory in 1% and poor/no response in 30% patients of Group B. Conclusion: This study concluded that Topical ciprofloxacin is more effective than oral ciprofloxacin in the medical treatment of tubo-tympanic type of CSOM to obtain dry ear.